Organic chemistry synthesis of aspirin and explain mechanism of reaction

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We will prepare a chemical compound, aspirin, from its primitive compounds. We will also discuss its importance and the importance of preparing aspirin. This is a fascinating chemistry experiment because it combines organic chemistry with medical applications. Aspirin (acetylsalicylic acid) is manufactured from salicylic acid and acetic acid (or acetic anhydride) in the presence of sulfuric acid or phosphoric acid as a catalyst.

Aspirin preparation (acetylsalicylic acid)

Raw materials:

Salicylic acid

Acetic anhydride

Sulfuric acid (catalyst)

distilled water

Reaction mechanism:

The reaction is esterification of the hydroxyl group of salicylic acid by acetic anhydride, resulting in the formation of an acetyl ester and the release of acetic acid as a byproduct.

1. Salicylic acid reacts with acetic anhydride.

2. Sulfuric acid breaks the bond in acetic anhydride, which helps the hydroxyl group in salicylic acid react with the acetic group.

3. Acetylsalicylic acid (aspirin) is formed with the release of acetic acid.

The importance of aspirin:

As a pain reliever and antipyretic

anti-inflammatory

It is used to prevent blood clots and heart disease.

Extra information

Bring your own pen and paper.

Location

Online from Germany

Age

Teenagers (13-17 years old)

Adults (18-64 years old)

Seniors (65+ years old)

Student level

Intermediate

Advanced

Duration

60 minutes

The class is taught in

Arabic

English

Skills

Chemistry

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(GMT -05:00)

New York

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04-08

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